A straightforward synthesis of both enantiomers of allo-norcoronamic acids and allo-coronamic acids, by asymmetric Strecker reaction from alkylcyclopropanone …
Methylcyclopropanone hemiacetal (2S)-3a underwent the asymmetric Strecker reaction induced by a chiral amine to provide a useful synthesis of enantiomerically pure (1R, 2S)-(+)- allo-norcoronamic acid 1 in good yield and high enantiomeric excess. From racemic alkyl hemiacetal (±)-3, the same methodology also constituted a useful way to prepare both (+)-1 and (−)-1 and (+)-allo-coronamic acid 2 and its antipode (−)-2 with good yield and high ...
