… of 3-Substituted 3H-Isobenzo-furan-1-ylidenamines by the Reaction of 2-Cyano-benzaldehydes with Organolithiums and Their Conversion into Isobenzofuran-1 …
Abstract–A new and efficient synthesis of 3-substituted 3H-isobenzofuran-1-ylidenamines by the reaction of 2-cyanobenzaldehydes with nucleophiles, such as organolithiums or lithium enolates of t-butyl acetate and N, N-dimethylacetamide, is reported. Some of these products were converted into the corresponding 3-substituted isobenzofuran-1 (3H)-ones (phthalides) upon treatment with hydrochloric acid in satisfactory yields.
