Tetrahedron

Synthesis and anticancer activity studies of novel 1-(2, 3-dihydro-5H-1, 4-benzodioxepin-3-yl) uracil and (6′-substituted)-7-or 9-(2, 3-dihydro-5H-1, 4-benzodioxepin- …

…, MG Pavani, M Díaz-Gavilán, F Rodríguez-Serrano…

文献索引：Nunez, Maria C.; Pavani, Maria G.; Diaz-Gavilan, Monica; Rodriguez-Serrano, Fernando; Gomez-Vidal, Jose A.; Marchal, Juan A.; Aranega, Antonia; Gallo, Miguel A.; Espinosa, Antonio; Campos, Joaquin M. Tetrahedron, 2006 , vol. 62, # 50 p. 11724 - 11733

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被引用次数: 22

摘要

On the basis of a molecular variation on an isosteric replacement (F→ H) from the prototype (RS)-1-(2, 3-dihydro-5H-1, 4-benzodioxepin-3-yl)-5-fluorouracil, the derivative (RS)-1-(2, 3- dihydro-5H-1, 4-benzodioxepin-3-yl) uracil 4 was prepared. Later on, the pyrimidine base was substituted by the purine moiety with the objective of increasing both the lipophilicity and the structural diversity of the target molecules. The 6′-halogen substituent of the (RS ...