Design of endoperoxides with anti-Candida activity

…, PI Macreadie, BW Greatrex, TV Robinson…

文献索引：Avery, Thomas D.; Macreadie, Peter I.; Greatrex, Ben W.; Robinson, Tony V.; Taylor, Dennis K.; Macreadie, Ian G. Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 1 p. 36 - 42

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被引用次数: 8

摘要

Broad antifungal structure–activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents.