Pyrido [4, 3 or 3, 4 or 2, 3-c]-1, 5-naphthyridines were obtained with good yields after chlorodehydroxylation and dehalogenation reactions starting from the parent pyridonaphthyridinones. These pyridonaphthyridinones were synthesized in a two-step procedure using a Suzuki cross-coupling reaction between 2-chloro-3-fluoropyridine and orthocyanopyridylboronic esters followed by a KOH-mediated anionic ring closure.
![5H-pyrido[3,4-c][1,5]naphthyridin-6-one结构式](https://image.chemsrc.com/caspic/299/923012-49-1.png)
![3-Fluoro-[2,3'-bipyridine]-4-carbonitrile结构式](https://www.chemsrc.com/extcaspic/337/923012-48-0.png)
![5H-pyrido[4,3-c][1,5]naphthyridin-6-one结构式](https://image.chemsrc.com/caspic/444/923012-50-4.png)
![pyrido[2,3-c]-1,5-naphthyridin-6(5H)-one结构式](https://image.chemsrc.com/caspic/355/14882-93-0.png)
![6-chloropyrido[2,3-c][1,5]naphthyridine结构式](https://image.chemsrc.com/caspic/406/923012-51-5.png)
![6-chloropyrido[4,3-c][1,5]naphthyridine结构式](https://image.chemsrc.com/caspic/330/923012-53-7.png)
![6-chloropyrido[3,4-c][1,5]naphthyridine结构式](https://image.chemsrc.com/caspic/368/923012-52-6.png)