Angiotensin converting enzyme inhibitors: N-substituted monocyclic and bicyclic amino acid derivatives

…, N Gruenfeld, JE Babiarz, MH Ackerman…

文献索引：Stanton; Gruenfeld; Babiarz; Ackerman; Friedmann; Yuan; Macchia Journal of Medicinal Chemistry, 1983 , vol. 26, # 9 p. 1267 - 1277

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被引用次数: 37

摘要

24 in the presence of 10% palladium on carbon. The quinaldic esters were prepared from the corresponding acids. The quinaldic acids either were commercially available (for 5a-c), were synthesized from commercially available quinolines by using the Reissert reaction" followed by hydrolysis (for 5d, f), or were prepared by the Skraup reaction followed by the Reissert sequence (50). Amino esters 6 needed for 19 were produced from 25 (Scheme ...