2-[(2-Pyridylmethyl) sulfinyl]-1H-thieno [3, 4-d] imidazoles. A novel class of gastric H+/K+-ATPase inhibitors

…, AW Herling, HJ Lang, KH Scheunemann…

文献索引：Weidmann, Klaus; Herling, Andreas W.; Lang, Hans-Jochen; Scheunemann, Karl-Heinz; Rippel, Robert; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 3 p. 438 - 450

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被引用次数: 24

摘要

2-[(2-Pyridylmethyl) sulfinyl] thienoimidazoles were synthesized and investigated as potential inhibitors of gastric H+/K+-ATPase. The [3, 4-d] isomers of the two possible thienoimidazole series were found to be potent inhibitors of gastric acid secretion in vitro and in vivo. Structure-activity relationships indicate that especially lipophilic alkoxy, benzyloxy, and phenoxy substituents with additional electron-demanding properties in the ...