P1 Phenethyl peptide boronic acid inhibitors of HCV NS3 protease

…, I De Lucca, B Ghavimi, S Erickson-Viitanen…

文献索引：Priestley; De Lucca, Indawati; Ghavimi, Bahman; Erickson-Viitanen, Susan; Decicco, Carl P. Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 21 p. 3199 - 3202

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被引用次数: 63

摘要

A series of peptide boronic acids containing extended, hydrophobic P1 residues was prepared to probe the shallow, hydrophobic S1 region of HCV NS3 protease. The p- trifluoromethylphenethyl P1 substituent was identified as optimal with respect to inhibitor potency for NS3 and selectivity against elastase and chymotrypsin.