Synthesis and in vitro evaluation of 2, 3-dimethoxy-5-(fluoroalkyl)-substituted benzamides: high-affinity ligands for CNS dopamine D2 receptors

…, JM Whitney, AM Eaton, RB Mailman

文献索引：Bishop; Mathis; Gerdes; Whitney; Eaton; Mailman Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1612 - 1624

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被引用次数: 47

摘要

A number of 2, 3-dimethoxy-5-(fluoroalkyl)-N-[(l-ethyl-2-p~ olidinyl) methylJ~~ id~(with or without a 6-hydroxy group) were synthesized and evaluated as dopamine D2 receptor ligands. The parent acids were synthesized via the Claisen rearrangement of the ...