Tetrahedron

Synthesis of 5-(sulfamoylmethyl) indoles

J Bosch, T Roca, M Armengol, D Fernández-Forner

文献索引：Bosch, Joan; Roca, Tomas; Armengol, Montserrat; Fernandez-Forner, Dolors Tetrahedron, 2001 , vol. 57, # 6 p. 1041 - 1048

全文：HTML全文

被引用次数: 55

摘要

The discovery of the anti-migraine drug sumatriptan (Imigran ® ) 1 has stimulated the search and design of second-generation 5-HT 1D receptor agonists. From the chemical point of view, many of these tryptamines (sumatriptan, 1 CP-122,288, 2 avitriptan, 3 almotriptan 4 ) have the common feature of possessing a sulfamoyl group attached at the indole 5 position through a methylene spacer (Fig. 1). ... In the context of the study of possible almotriptan ...