Tetrahedron

Preparation of 1-aminoalkylphosphonic acids and 2-aminoalkylphosphonic acids by reductive amination of oxoalkylphosphonates

A Ryglowski, P Kafarski

文献索引：Ryglowski, Artur; Kafarski, Pawel Tetrahedron, 1996 , vol. 52, # 32 p. 10685 - 10692

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被引用次数: 51

摘要

By reacting dialkyl 1-oxo-or 2-oxoalkylphosphonates with benzhydrylamine followed by reduction with triacetoxyborohydride and acid hydrolysis gave corresponding aminoalkylphosphonic acids with satisfactory yields. The use of benzylamine, α- methylbenzylamine and tritylamine was unsuccessful in the case of dialkyl 1- oxoalkylphosphonates whereas conversion of 2-oxoalkylphosphonates was also ...