Synthesis, docking, and in vitro activity of thiosemicarbazones, aminoacyl-thiosemicarbazides and acyl-thiazolidones against Trypanosoma cruzi

…, LMF dos Santos, MZ Hernandes, AC Kiperstok…

文献索引：Leite, Ana Cristina Lima; de Lima, Renata Souza; Moreira, Diogo Rodrigo de M.; Cardoso, Marcos Verissimo de O.; Gouveia de Brito, Ana Carolina; Farias dos Santos, Luciene Maria; Hernandes, Marcelo Zaldini; Kiperstok, Alice Costa; de Lima, Ricardo Santana; Soares, Milena B.P. Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 11 p. 3749 - 3757

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被引用次数: 90

摘要

A novel series of thiosemicarbazone and aminoacyl-thiazolidones derivatives were synthesized. Their structure suggests that these compounds could have anti-Trypanosoma cruzi activity. Biological evaluation indicates that some of these compounds are able to inhibit the growth of T. cruzi in concentrations non-cytotoxic to mammalian cells. Docking studies were carried out in order to investigate the binding pattern of these compounds for ...