Bis-cationic heteroaromatics as macrofilaricides: synthesis of bis-amidine and bis-guanylhydrazone derivatives of substituted imidazo [1, 2-a] pyridines

RJ Sundberg, S Biswas, K Kumar Murthi…

文献索引：Sundberg, Richard J.; Biswas, Sujay; Murthi, Krishna Kumar; Rowe, Donna; McCall, John W.; Dzimianski, Michael T. Journal of Medicinal Chemistry, 1998 , vol. 41, # 22 p. 4317 - 4328

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被引用次数: 31

摘要

A series of guanylhydrazone, amidine, and hydrazone derivatives of 2-phenylimidazo [1, 2- a] pyridine have been prepared and evaluated for macrofilarial activity against Acanthocheilonema viteae and Brugia pahangi in jirds. Compounds with 4', 6-bis- substitution by cyclic guanylhydrazone groups show activity. 4', 6-Bis-amidines show some activity but are more toxic; 4'-or 6-monosubstituted compounds are inactive. 2, 6-Bis- ...