Synthesis and evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae

M Yamashita, M Kaneko, H Tokuda, K Nishimura…

文献索引：Yamashita, Mitsuaki; Kaneko, Masafumi; Tokuda, Harukuni; Nishimura, Katsumi; Kumeda, Yuko; Iida, Akira Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 17 p. 6286 - 6291

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被引用次数: 29

摘要

A series of naphthoquinones based on the naphtho [2, 3-b] furan-4, 9-dione skeleton such as (−)-5-hydroxy-2-(1′-hydoxyethyl) naphtho [2, 3-b] furan-4, 9-dione (1) and its positional isomer,(−)-8-hydroxy-2-(1′-hydoxyethyl) naphtho [2, 3-b] furan-4, 9-dione (2), which are secondary metabolites found in the inner bark of Tabebuia avellanedae, were stereoselectively synthesized and their biological activities were evaluated in conjunction ...