Abstract Based on the reactive behavior of different transition-metal catalysts, three methods for the synthesis of highly functionalized polysubstituted furan derivatives are presented:(i) copper (I) iodide catalyzed regiospecific synthesis of furan aldehydes/ketones from alkynols and diethyl but-2-ynedioate under atmospheric pressure;(ii) nano-Cu 2 O-catalyzed domino process for the regioselective synthesis of α-carbonylfurans from readily accessible ...