Synthesis

An expeditious one-pot synthesis of Thiiranes from α-halo ketones in solvent-free conditions using microwaves

LDS Yadav, R Kapoor

文献索引：Yadav, Lal Dhar S.; Kapoor, Ritu Synthesis, 2002 , # 16 p. 2344 - 2346

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被引用次数: 14

摘要

The envisaged synthesis of 3 from 1 in its entirety involves a simple mixing of an α -halo ketone 1, O,O-diethyl hydrogen phosphorodithioate 2 and alumina-supported sodium borohydride followed by irradiating the mixture in an unmodified domestic microwave oven for the time specified in Table [1] . The extraction of the product into dichloromethane affords thiiranes 3 in excellent yields (81-94%) and diastereoselectivity (89-100%) (Table [1] ). For comparison purposes, the ...