Metabolism of 7??ethoxycoumarin, safrole, flavanone and hydroxyflavanone by cytochrome P450 2A6 variants

…, K Kanamaru, H Yamagata, H Imaishi

文献索引：Uno, Tomohide; Obe, Yuichiro; Ogura, Chika; Goto, Tatsushi; Yamamoto, Kohei; Nakamura, Masahiko; Kanamaru, Kengo; Yamagata, Hiroshi; Imaishi, Hiromasa Biopharmaceutics and Drug Disposition, 2013 , vol. 34, # 2 p. 87 - 97

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被引用次数: 4

摘要

ABSTRACT CYP 2A6 is a human enzyme that metabolizes many xenobiotics including coumarin, indole, nicotine and carcinogenic nitrosamines. The gene for CYP2A6 is polymorphic. There are few data available to clarify the relationship between P450 genetic variants and the metabolism of materials in food. The CYP 2A6 wild-type protein and 13 mutants (CYP2A6. 1, CYP2A6. 2, CYP2A6. 5, CYP2A6. 6, CYP2A6. 7, CYP2A6. 8, ...