Tetrahedron

Total synthesis of (±)-paniculide-a

PA Jacobi, CSR Kaczmarek, UE Udodong

文献索引：Jacobi, Peter A.; Kaczmarek, Colleen S.R.; Udodong, Uko E. Tetrahedron, 1987 , vol. 43, # 23 p. 5475 - 5488

全文：HTML全文

被引用次数: 37

摘要

An efficient synthesis of the paniculide A precursor 4 has been achieved beginning with 3- methylglutaric anhydride, and utilizing as the key step an intramolecular Diels-Alder reaction of an acetylenic oxazole to give a 2-methoxyfuran. Acid hydrolysis then provided the requisite butenolide ring characteristic of the paniculides.