Structure activity studies of the serine-AIB dipeptide domain in 2, 3-dihydroisothiazole based growth hormone secretagogues

…, JA Dodge, D Hankotius, U Hary, LN Jungheim…

文献索引：Evers, Britta; Ruehter, Gerd; Berg, Martina; Dodge, Jeffrey A.; Hankotius, Dirk; Hary, Ulrike; Jungheim, Louis N.; Mest, Hans-Juergen; De La Nava, Eva-Maria Martin; Mohr, Michael; Muehl, Brian S.; Petersen, Soenke; Sommer, Birgit; Riedel-Herold, Grit; Tebbe, Mark J.; Thrasher, Kenneth J.; Voelkers, Silke Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 24 p. 6748 - 6762

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被引用次数: 6

摘要

A series of growth hormone secretagogues (GHSs) based on 2, 3-dihydroisothiazole has been synthesized in the search for a potential treatment of growth hormone deficiency or frailty in the elderly. This paper describes the evaluation of the SAR of the benzyl-d-Ser- aminoisobutyric acid dipeptide fragment. Introduction of substituents in the peptide backbone and in the phenyl ring has been investigated, as well as replacements for the ...