Journal of medicinal chemistry

Synthesis of. alpha.-heterosubstituted nitrosamines. Novel test substances for cancer and mutagenesis research

D Seebach, D Enders

文献索引：Seebach,D.; Enders,D. Journal of Medicinal Chemistry, 1974 , vol. 17, p. 1225 - 1227

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被引用次数: 10

摘要

methods used in tyrosine hydroxylase purification and assay were the same as previously reported. 14J5 Tyrosine hydroxylase kinetics were determined by the method of Lineweaver- Burk16 with substrate concentrations varying from 6 X to M and by the method of Dixon17 with substrate concentrations set at 5 x and at 1 X M. DMPH4 concentration was constant in the inhibition studies at 10-3 M but was later varied between 1