The synthesis of possible hydroxylated metabolites of 2??chlorophenothiazine derivatives

A Zirnis, JK Suzuki, DE Dickson…

文献索引：Zirnis; Suzuki; Dickson; et al. Journal of Heterocyclic Chemistry, 1977 , vol. 14, # 1 p. 107 - 112

全文：HTML全文

被引用次数: 2

摘要

Abstract The synthesis of 7-hydroxy, 8-hydroxy and 7, 8-dihydroxy prochlorperazines (3a) and per-phenazines (3b) is reported. The parent ehlorophenothiazines were prepared analogously to previously reported chlorpromazine (3e) metabolite syntheses. The prochlorperazine side chain was introduced in one step using 1-(3-chloropropyl)-4- methylpiperazine and the perphenazine side chain in two steps, first reaction with 1- ...