Tetrahedron

A simple one-pot three-component reaction for preparation of secondary amines and amino esters mediated by lithium perchlorate

MR Saidi, N Azizi, H Zali-Boinee

文献索引：Saidi, Mohammad R; Azizi, Najmoddin; Zali-Boinee, Hasan Tetrahedron, 2001 , vol. 57, # 31 p. 6829 - 6832

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被引用次数: 32

摘要

The one-pot synthesis of several secondary amines and secondary amino esters are reported. Treatment of aldehydes (aliphatic or aromatic) with (trimethylsilyl) alkylamines, in the presence of 5M lithium perchlorate in diethyl ether gives intermediate imines. Reaction of these intermediate imines with different nucleophiles and functionalized organozinc reagents, BrZnCH2COOR, produce a variety of secondary amines and N-alkyl-or N- ...