Structure-activity relationships in a series of novel 3, 4-dihydro-4-oxopyrimido [4, 5-b] quinoline-2-carboxylic acid antiallergy agents

…, SB Kadin, LJ Czuba, PF Moore, HJ Hess

文献索引：Althuis, T. H.; Kadin, S. B.; Czuba, L. J.; Moore, P. F.; Hess, H.-J. Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 262 - 269

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被引用次数: 27

摘要

A series of more than 50 new 3, 4-dihydro-4-oxopyrimido [4, 5-b] quinoline-2-carboxylic acid derivatives and related compounds with substituent variations at the 2, 3, and 5-9 positions was prepared and evaluated for antiallergy activity using the rat PCA assay. These compounds were obtained by the condensation of the appropriately substituted 2- aminoquinoline-3-carboxamides with dialkyl oxalates, followed by further chemical ...