The design and development of 2-aryl-2-hydroxy ethylamine substituted 1H, 7H-pyrido [1, 2, 3-de] quinoxaline-6-carboxamides as inhibitors of human …

SP Tanis, JW Strohbach, TT Parker, MW Moon…

文献索引：Tanis, Steven P.; Strohbach, Joseph W.; Parker, Timothy T.; Moon, Malcom W.; Thaisrivongs, Suvit; Perrault, William R.; Hopkins, Todd A.; Knechtel, Mary L.; Oien, Nancee L.; Wieber, Janet L.; Stephanski, Kevin J.; Wathen, Michael W. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 6 p. 1994 - 2000

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被引用次数: 19

摘要

Discovery efforts were focused on identifying a non-nucleoside antiviral for treating infections caused by human cytomegalovirus (HCMV) with equal or better potency and diminished toxicity compared to current therapeutics. This Letter describes the HCMV DNA polymerase inhibition and in vitro antiviral activity of various 2-aryl-2-hydroxy ethylamine substituted 1H, 7H-pyrido [1, 2, 3-de] quinoxaline-6-carboxamides.