Thromboxane synthetase inhibitors and antihypertensive agents. 1. N-[(1H-imidazol-1-yl) alkyl] aryl amides and N-[(1H-1, 2, 4-triazol-1-yl) alkyl] aryl amides

…, JW Marsico, MF Haug, J Lucas, J Tauber…

文献索引：Wright Jr.; Press; Chan; Marsico; Haug; Lucas; Tauber; Tomcufcik Journal of Medicinal Chemistry, 1986 , vol. 29, # 4 p. 523 - 530

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被引用次数: 39

摘要

The title compounds were prepared to investigate their potential as thromboxane synthetase inhibitors as well as antihypertensive agents. Imidazoles VI11 and triazoles X were prepared to examine the effects of aromatic substitution, chain length, and heterocycle substitution upon biological activity. Imidazoles VI11 and triazoles X were thromboxane synthetase inhibitors that did not inhibit prostacyclin formation. The most interesting thromboxane ...