Design and synthesis of new 2-substituted-5-(2-benzylthiophenyl)-1, 3, 4-oxadiazoles as benzodiazepine receptor agonists

…, HR Khojastehpoor, V Zanganeh, SA Tabatabai…

文献索引：Zarghi, Afshin; Faizi, Mehrdad; Shafaghi, Bijan; Ahadian, Avideh; Khojastehpoor, Hamid R.; Zanganeh, Vahideh; Tabatabai, Sayyed A.; Shafiee, Abbas Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 12 p. 3126 - 3129

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被引用次数: 64

摘要

A series of new 2-substituted-5-(2-benzylthiophenyl)-1, 3, 4-oxadiazoles was designed and synthesized as anticonvulsant agents. Conformational analysis and superimposition of energy minima conformers of the designed molecules on estazolam, a known benzodiazepine receptor agonist, revealed that the main proposed benzodiazepine pharmacophores were well matched. Electroshock and pentylenetetrazole-induced lethal ...