The Journal of Organic Chemistry

Folate analogs. 17. Synthesis of pteroic acid and 4-amino-4-deoxypteroic acid

MG Nair, SR Adapa, T Bridges

文献索引：Nair; Adapa; Bridges Journal of Organic Chemistry, 1981 , vol. 46, # 15 p. 3152 - 3155

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被引用次数: 5

摘要

In connection with our studies concerning the development of synthetic substrates2 of the enzyme dihydrofolate reductase (EC 1.5. 1.3) it occurred to us that the protected bromomethyl ketone 6 would be a useful intermediate for the construction of certain classical