Synthesis and antimicrobial studies on novel chloro-fluorine containing hydroxy pyrazolines

MS Karthikeyan, BS Holla, NS Kumari

文献索引：Karthikeyan, Mari Sithambaram; Holla, Bantwal Shivarama; Kumari, Nalilu Suchetha European Journal of Medicinal Chemistry, 2007 , vol. 42, # 1 p. 30 - 36

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被引用次数: 135

摘要

A series of chloro-fluorine containing chalcones (3) were prepared by Claisen–Schmidt condensation. Chalcone dibromides (4) were obtained by the bromination of chalcones at room temperature. Treatment of chalcone dibromides (4) with aryloxy acid hydrazides (5) in the presence of triethylamine gave chloro-fluorine containing hydroxy pyrazolines (7) rather than the expected 1-aryloxy-3-aryl-5-aryl pyrazoles (6). The structures of the newly ...