Synthesis and antiviral activities of N-9-oxypurine 1, 3-Dioxolane and 1, 3-oxathiolane nucleosides

N Nguyen-Ba, N Lee, L Chan, B Zacharie

文献索引：Nguyen-Ba, Nghe; Lee, Nola; Chan, Laval; Zacharie, Boulos Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 19 p. 2223 - 2226

全文：HTML全文

被引用次数: 14

摘要

Two series of 1, 3-dioxolanes and 1, 3-oxathiolane nucleosides containing N-9-oxypurine were synthesized as potential antiviral agents. These compounds were prepared by reacting the sugar moieties with iodo-or bromotrimethylsilane, followed by treatment with a mixture of sodium hydride and the desired N-hydroxy purine base. The preparation of these N- hydroxybases was also described. No significant antiviral activity was observed against ...