Bioorganic & medicinal chemistry letters

Neuroprotective or neurotoxic activity of 1-methyl-1, 2, 3, 4-tetrahydroisoquinoline and related compounds

K Okuda, Y Kotake, S Ohta

文献索引：Okuda, Katsuhiro; Kotake, Yaichiro; Ohta, Shigeru Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 17 p. 2853 - 2855

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被引用次数: 32

摘要

1-Methyl-1, 2, 3, 4-tetrahydroisoquinoline (1MeTIQ) 1 and various 5-or 6, 7-substituted analogues were synthesized and assayed for neurotoxicity towards SH-SY5Y cells. Among mono-substituted derivatives of 1, hydroxyl substitution decreased the toxicity, while methoxyl substitution increased it. Disubstituted derivatives of 1, 5a and 5b, showed the opposite tendency. Hydroxy-1MeTIQ derivatives were tested for neuroprotective activity, ...