Study of chemical carcinogenesis. 22. Synthesis of dihydro diols as potential proximate carcinogens of benzofluoranthenes

S Amin, V Bedenko, E LaVoie, SS Hecht…

文献索引：Amin, Shantilal; Bedenko, Victoria; LaVoie, Edmond; Hecht, Stephen S.; Hoffmann, Dietrich Journal of Organic Chemistry, 1981 , vol. 46, # 12 p. 2573 - 2578

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被引用次数: 10

摘要

Dihydro diols which are potential proximate carcinogens of the environmental agents benzo [b] fluoranthene (l), benzoLjlfluoranthene (Z), and benzo [k] fluoranthene (3) were synthesized. The dihydro diols synthesized were trans-9, 10-dihydro-9, 10-dihydroxybenzo [blfluoranthene (5), truns-9, 10-dihydro-9, lO-dihydroxybenzo~]-fluoranthene (6), and trans- 8, 9-dihydro-8, 9-dihydroxybenzo [k] fluoranthene (7). In each case, the precursor to the ...