Novel Histamine H3-Receptor Antagonists with Carbonyl-Substituted 4-(3-(Phenoxy) propyl)-1 H-imidazole Structures like Ciproxifan and Related Compounds

…, JM Arrang, JC Schwartz, W Schunack

文献索引：Krause; Ligneau; Stark; Garbarg; Schwartz; Schunack Journal of Medicinal Chemistry, 1998 , vol. 41, # 21 p. 4171 - 4176

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被引用次数: 43

摘要

Novel histamine H3-receptor antagonists possessing a 4-(3-(phenoxy) propyl)-1 H- imidazole structure generally substituted in the para-position of the phenyl ring have been synthesized according to Mitsunobu or SNAr reactions. With in vitro and in vivo screening for H3-receptor antagonist potency, the carbonyl-substituted derivatives proved to be highly active compounds. A number of compounds showed in vitro affinities in the subnanomolar ...