Chemical and enzymatic routes to methoxydopamines

J Daly, L Horner, B Witkop

文献索引：Daly,J. et al. Journal of the American Chemical Society, 1961 , vol. 83, p. 4787 - 4792

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被引用次数: 36

摘要

OMe XI yields of less than lg/, of a material analyzing correctly for the desired 4-benzyloxy-5- hydroxy-2-rnethoxybenzaldehyde (XI). The successful synthesis of methoxycatecholamine I started with 4, 5-methylenedioxy-2-meth-oxybenzaldehvde (XII) l1 which was condensed with nitromethane to yield the nitrostyrene (XIII). Reduction of XIII with hydrogen and palladiumon-charcoal yielded 4, 5-methylenedioxy-2-methoxyphenethylamine ...