Relative reactivity and stereoselectivity in the Wittig reactions of substituted benzaldehydes with benzylidenetriphenylphosphorane

H Yamataka, K Nagareda, K Ando…

文献索引：Yamataka, Hiroshi; Nagareda, Katsushi; Ando, Katsuhiro; Hanafusa, Terukiyo Journal of Organic Chemistry, 1992 , vol. 57, # 10 p. 2865 - 2869

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被引用次数: 60

摘要

Carbonyl carbon-14 kinetic isotope effects and substituent effects on the relative reactivity and on the cis-trans product ratio were determined in the Wittig reaction of XCBH4CH0 with Ph3P= CHCsH4Y in THF at 0" C. The isotope effect and the Hammett p value were positive under both Li salt-free (12k/14k= 1.060 i 0.003 and px= 2.77 i 0.15) and Li salt-present (12k/" k= 1.015 i 0.004 and px= 1.38 i 0.12) conditions, although they were much larger in the ...