Synthesis of phospholipids via phosphotriester intermediates

JG Lammers, JH Van Boom

文献索引：Lammers,J.G.; van Boom,J.H. Recueil des Travaux Chimiques des Pays-Bas, 1979 , vol. 98, p. 243 - 250

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被引用次数: 18

摘要

Abstract A new phospholipid synthesis has been developed. Phosphorylation of a 1, 2 diacylglycerol with the monofunctional reagent R 1 R 2 POCl (R 1 and R 2 being phosphate- protecting groups) provides a phosphotriester in 70–90% yield. Removal of one protecting group affords a phosphodiester, which is condensed with the required alcohol to a second phosphotriester (70–75% yield, based on the first triester). Subsequently, the other ...