Organic process research & development

Solvent applications of 2-methyltetrahydrofuran in organometallic and biphasic reactions

DF Aycock

文献索引：Aycock, David F. Organic Process Research and Development, 2007 , vol. 11, # 1 p. 156 - 159

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被引用次数: 175

摘要

2-Methyltetrahydrofuran (MeTHF) is a commercially available solvent that is produced from renewable resources. The properties of MeTHF place it between tetrahydrofuran (THF) and diethyl ether in solvent polarity and Lewis base strength. In many cases, MeTHF can replace THF in organometallic reactions. The formation and reaction of Grignard reagents in MeTHF and THF are similar. MeTHF can be used as a solvent for low-temperature lithiation, for ...