Indole RSK inhibitors. Part 2: optimization of cell potency and kinase selectivity

TM Kirrane, SJ Boyer, J Burke, X Guo, RJ Snow…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 1 p. 738 - 742

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被引用次数: 15

摘要

... Bioorganic & Medicinal Chemistry Letters. ... a Department of Medicinal Chemistry, Boehringer-Ingelheim ... Moreover, the chemistry to make the pyrazoles allowed access to a wider range of ring substituents that were not readily achievable in the isoxazole series, such as the ...