The ionization and poor lipid solubility of carboxylic acid containing drugs compromises their permeability across biological membranes like skin. Prodrugs, which are biologically inactive derivatives of a drug and which hydrolyze in vivo to the pharmacologically active drug molecule, are useful in breaching biological barriers. Various prodrug ester based approaches utilizing a simple alkyl group in the ester promoiety have been used in the past to improve ...
