Design and synthesis of potent and highly selective thrombin inhibitors

K Hilpert, J Ackermann, DW Banner…

文献索引：Journal of Medicinal Chemistry, , vol. 37, # 23 p. 3889 - 3901

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被引用次数: 187

摘要

... Hirudin: a polypeptide isolated from the medical leech, is currently in phase I11 clinical trials6.as is Hirulog-8,7 one of a series of peptide inhibitors derived from hirudin. ... Page 2. 3890 Journal of Medicinal Chemistry, 1994, Vol. 37, No. 23 ...