Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure–activity relationship

…, N Handler, T Erker, K Pleban, G Ecker, P Saiko…

文献索引：Murias, Marek; Handler, Norbert; Erker, Thomas; Pleban, Karin; Ecker, Gerhard; Saiko, Philipp; Szekeres, Thomas; Jaeger, Walter Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 21 p. 5571 - 5578

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被引用次数: 263

摘要

Resveratrol (3, 5, 4′-trihydroxy-trans-stilbene) is found in grapes and various medical plants. Among cytotoxic, antifungal, antibacterial cardioprotective activity resveratrol also demonstrates non-selective cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibition. In order to find more selective COX-2 inhibitors a series of methoxylated and hydroxylated resveratrol derivatives were synthesized and evaluated for their ability to ...