Nitrogenous organosilicon compounds. CX. Synthesis and pharmacological study of organosilicon aminoalcohols and their derivatives

…, MM Veveris, ZA Atare, ID Segal, LN Khokhlova…

文献索引：Lukevits, E.; Veveris, M. M.; Atare, Z. A.; Segal, I. D.; Khokhlova, L. N.; Kimenis, A. A. Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 10 p. 764 - 768 Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 10 p. 1204 - 1209

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摘要

The curariform and ganglion-blocking activity of the compounds were studied, together with their effects on the blood circulatory system and modification of the effects of biogenic amines. Acute toxicities were also determined. The pharmacological studies showed that in experiments with narcotized cats, several of the compounds showed curariform activity when administered by the intravenous route (Table 3), but the doses were relatively high, and ...