Chemical biology & drug design

Praziquantel derivatives with antischistosomal activity: aromatic ring modification

Z Wang, J Chen, C Qiao

文献索引：Wang, Zhi-Xia; Chen, Jing-Lei; Qiao, Chunhua Chemical Biology and Drug Design, 2013 , vol. 82, # 2 p. 216 - 225

全文：HTML全文

被引用次数: 6

摘要

A series of aromatic ring-modified praziquantel derivatives were prepared and evaluated against juvenile and adult stage of Schistosoma japonicumin. Several analogs comparable in activity to the drug praziquantel have been identified based on in vitro and in vivo japonuicum schistosomes worm viability assay. Structure and activity relationship of these praziquantel aromatic ring-modified compounds was revealed. Specifically, a compound ...