4-Heterocyclyl tetrahydropyridines as selective ligands for the human dopamine D 4 receptor

…, M Fielding, K Chapman, F Emms, R Marwood…

文献索引：Haworth; Harrison; Kulagowski; Leeson; Owens; Ridgill; Teall; Fielding; Chapman; Emms; Marwood; Patel; Moss Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 17 p. 2211 - 2216

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被引用次数: 4

摘要

A series of 1, 2, 3, 6-tetrahydropyridines 3 were synthesised, which resulted in selective high affinity dopamine D4 ligands. The SAR of heterocyclic replacements and aromatic substitution was investigated, leading to compounds of nanomolar binding affinity with excellent selectivity over both D2 and D3 receptors.