(Mercaptopropanoyl) indoline-2-carboxylic acids and related compounds as potent angiotensin converting enzyme inhibitors and antihypertensive agents

…, CJ Guinosso, GC Buzby Jr, DR Herbst…

文献索引：Kim, Dong H.; Guinosso, Charles J.; Buzby, George C.; Herbst, David R.; McCaully, Ronald J.; et al. Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 394 - 403

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被引用次数: 57

摘要

1-(3-Mercapto-2-methyl-l-oxopropyl) indoline-2-carboxylic acids (7b) and related compounds were synthesized in order to examine their ability to inhibit angiotensin converting enzyme (ACE) and to reduce the systolic blood pressure of spontaneously hypertensive rats (SHR). All four possible stereoisomers of the precursor 1-[3-(benzoylthio)- 2-methyl-l-oxopropyl] indoline-2-carboxylic acid (6b) were characterized with absolute ...