Alkylation of diethyl 5, 6, 7, 8-tetrahydro-8-deazafolate with 3'-0-acetyl-5-(bromomethyl)-2'- deoxyuridine 5'-[bis-(trichlorethyl) phosphate], followed by removal of the trichloroethyl groups with a Zn/Cu couple and mild saponification, gave the target inhibitor N-[4-[[[2-amin0- 3, 4, 5, 6, 7, 8-hexahydro-4-0~ 0-5-[(2'-deoxyuridin-5-yl) methyl]-pyrido [3, 2-d] pyrimidin-6-yl] methyl] amino] benzoyl]-~-glutamic acid 5'-monophosphate. The free nucleoside and the 5 ...
![2-amino-5,6,7,8-tetrahydro-6-methylpyrido[3,2-d]pyrimidin-4(3H)-one结构式](https://image.chemsrc.com/caspic/166/78711-33-8.png)
![diethyl 2-[[4-[(9-amino-7-oxo-5,8,10-triazabicyclo[4.4.0]deca-8,11-dien-4-yl)methylamino]benzoyl]amino]pentanedioate结构式](https://image.chemsrc.com/caspic/087/82855-85-4.png)
![2-[[4-[[2-amino-5-[[1-[4-hydroxy-5-(phosphonooxymethyl)oxolan-2-yl]-2,4-dioxopyrimidin-5-yl]methyl]-4-oxo-1,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl]methylamino]benzoyl]amino]pentanedioic acid结构式](https://image.chemsrc.com/caspic/006/92008-00-9.png)
![Acetic acid (2R,3S,5R)-2-[bis-(2,2,2-trichloro-ethoxy)-phosphoryloxymethyl]-5-(5-bromomethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester结构式](https://image.chemsrc.com/caspic/354/88543-89-9.png)
