(5-Arylfuran-2-ylcarbonyl) guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1

S Lee, KY Yi, SK Hwang, BH Lee, S Yoo…

文献索引：Lee, Sunkyung; Yi, Kyu Yang; Hwang, Sun Kyung; Lee, Byung Ho; Yoo, Sung-Eun; Lee, Kyunghee Journal of Medicinal Chemistry, 2005 , vol. 48, # 8 p. 2882 - 2891

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被引用次数: 34

摘要

A series of (5-arylfuran-2-ylcarbonyl) guanidines was synthesized and evaluated for the NHE-1 inhibitory activity and cardiprotective efficacy against ischemia-reperfusion injury. Starting with (5-phenylfuran-2-ylcarbonyl) guanidine 47 with a moderate inhibitory effect on NHE-1, the compounds with various substituents at the phenyl ring were investigated with the aim to optimize the potency. In this study, the 2, 5-disubstituted compounds appeared ...