Synthesis and in vitro stability of nucleoside 5′-phosphonate derivatives

S Vertuani, A Baldisserotto, K Varani, PA Borea…

文献索引：Vertuani, Silvia; Baldisserotto, Anna; Varani, Katia; Borea, Pier Andrea; De Marcos Maria Cruz, Bonache; Ferraro, Luca; Manfredini, Stefano; Dalpiaz, Alessandro European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 202 - 209

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被引用次数: 2

摘要

Nucleoside derivatives are largely synthesized and tested to investigate their influence on platelet aggregation. It's well known that P2Y receptors play an important role in the regulation of platelet function and, as consequence, in controlling atherothrombotic events. The research of compounds that antagonize P2Y1 and, in particular, P2Y12 receptors is of great interest in the aim to obtain platelet aggregation inhibitors that are effective in the ...