Antioxidant-based inhibitors of leukotriene biosynthesis. The discovery of 6-[1-[2-(hydroxymethyl) phenyl]-1-propen-3-yl]-2, 3-dihydro-5-benzofuranol, a potent topical …

ML Hammond, RA Zambias, MN Chang…

文献索引：Hammond, Milton L.; Zambias, Robert A.; Chang, Michael N.; Jensen, Norman P.; McDonald, John; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 3 p. 909 - 918

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被引用次数: 51

摘要

We have recently reported a series of 2, 3-dihydro-5-benzofuranols that are potent antioxidant-based inhibitors of leukotriene biosynthesis in human PMNs.'O In particular we pointed out that within this series the ability to inhibit leukotriene biosynthesis is directly correlated with the overall lipophilicity of the molecule. We now report our earlier studies in this area in which several closely related ring systems were compared and the 2, 3- ...