Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant α4β2 nicotinic acetylcholine receptor potentiators

BK Albrecht, V Berry, AA Boezio, L Cao…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 19 p. 5209 - 5212

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被引用次数: 20

摘要

... Bioorganic & Medicinal Chemistry Letters. ... a Department of Medicinal Chemistry, Amgen Inc., One ... This chemistry is outlined in Scheme 2. Treatment of heterocyclic aldehydes 8 under Bestmann–Ohira conditions afforded the corresponding alkynes 9 (Scheme 2). 1,3-Dipolar ...