Detoxification system for inorganic arsenic: transformation of As2O3 into TMAO by vitamin B12 derivatives and conversion of TMAO into arsenobetaine

K Nakamura, Y Hisaeda, L Pan…

文献索引：Nakamura, Koichiro; Hisaeda, Yoshio; Pan, Ling; Yamauchi, Hiroshi Chemical Communications, 2008 , # 41 p. 5122 - 5124

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被引用次数: 16

摘要

A new two-step synthetic pathway developed for the transformation of arsenic trioxide [iAs (III); As2O3] into arsenobetaine (AB; Me3As+ CH2CO2−) involves treatment of iAs (III) with native B12 or biomimetic B12 in the presence of glutathione (GSH) to give TMAO with a high selectivity and a high conversion rate; subsequent treatment of TMAO with iodoacetic acid in the presence of GSH gives arsenobetaine.